Masahiro Ono, MD

Cardiac Surgery

Methodist Physicians Cardiothoracic Surgery Specialists
4499 Medical Dr Ste 166
San Antonio, TX 78229



Masahiro Ono, MD, PhD is a Heart Transplant and Mechanical Circulatory Support Surgeon. He performs high-risk, advanced heart failure therapeutics with Methodist Hospital's Advanced Heart Failure and Transplant program.

For Dr. Ono, a great day is one where very complicated and challenging surgeries go well: "The OR team and I start to prepare the day before, and when the cases go well, I feel like my effort and everyone's efforts are like a chemical reaction in the OR. And, then, when I bring the patient back for a follow-up, everyone is happy!" says Dr. Ono.

Dr. Ono was inspired to pursue a career as a surgeon early on. His father, a maxillofacial surgeon in Japan, was his primary influence. Later, after medical school and a general surgery residency at Showa University School of Medicine in Tokyo, it became clear that cardiac surgery would be his chosen subspecialty where the most acute cases offered both the greatest challenge and the greatest reward. Dr. Ono completed his cardiothoracic surgery fellowship and a PhD at Showa University. He would soon discover, however, that some patients with advanced heart failure were too sick for surgery and he decided to relocate to the United States to train in cardiac transplant and mechanical circulatory support.

Once in the US, Dr. Ono completed a postdoctoral research fellowship at Johns Hopkins Hospital in Baltimore, Maryland. He then secured a cardiovascular surgery fellowship at Texas Heart Institute at Baylor St. Luke's Medical Center in Houston, Texas followed by a cardiothoracic transplant and mechanical circulatory support surgery fellowship there. Before joining Methodist, Dr. Ono practiced with Texas Heart Institute where he served as Assistant Professor in the Division of Cardiothoracic Transplant & Circulatory Support in the Michel E. DeBakey Department of Surgery at Baylor College of Medicine.

Dr. Ono is the recipient of numerous research and teaching awards, including most recently the Chief Award to an Outstanding Faculty Member Selected by the Graduating Chief Residents in Cardiothoracic Surgery at Michel E. DeBakey Department of Surgery, Baylor College of Medicine. He is a member of several professional organizations, including the Japanese Surgical Society, Japanese Association for Thoracic Surgery, Japanese Society for Cardiovascular Surgery and the International Society for Heart & Lung Transplantation.

Care Philosophy

Dr. Ono makes every effort to spend as much time as possible with his patients and their families so they can connect with him and feel comfortable asking all their questions.

Procedures and Conditions Treated
  • Telehealth
  • Impella
  • Heart Transplant Surgery
  • Ventricular Assist Device Implantation and Management
  • Cardiothoracic Transplant
  • Advanced Heart Failure
  • TandemHeart
  • Cardio-Thoracic Surgery
  • HeartAssist 5
  • Thoratec pVAD and Thoratec iVAD Bridge to Recovery
  • Cardiovascular Surgery
  • Bridge to Transplant
  • Cardiac Device Implantation
  • Mechanical Circulatory Support (MCS)
  • Cardiac Transplantation
  • CentriMag
  • HeartMate II
  • Post-Cardiotomy Shock
  • Destination Therapy Left Ventricular Assist Devices (DT LVAD)
  • HeartMate XVE
Credentials and Education
  • Showa University School of Medicine
    Graduate Degree - 2003

  • Showa University School of Medicine
    Residency - 2005

  • Showa University School of Japan
    Fellowship - 2010

  • John Hopkins Hospital
    Fellowship - 2013

  • Texas Heart Institute
    Fellowship - 2014

  • Texas Heart Institute
    Fellowship - 2016


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